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The framework from the unliganded double mutant HIV-1 RT showed that Lys103Asn mutation facilitates coordination of the sodium ion with Lys101 O, Asn103 N and O(delta1), Tyr188 O(eta), and two h2o molecules. The development of your binding pocket necessitates the removal of your sodium ion. Although the RT by yourself and also the RT/HBY 097 advanc